Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
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چکیده
منابع مشابه
Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
Known molecular determinants of developmental plasticity are mainly transcription factors, while the extrinsic regulation of this process has been largely unexplored. Here we identify Cripto as one of the earliest epiblast markers and a key extracellular determinant of the naive and primed pluripotent states. We demonstrate that Cripto sustains mouse embryonic stem cell (ESC) self-renewal by mo...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2016
ISSN: 2041-1723
DOI: 10.1038/ncomms12589